Assess and Evaluation the Quality Of Life (Qol) Among Cancer Patients Undergoing Treatment by Using EORTC QLQ-30 Scale

Background: Cancer is a challenge for majority of population抯 health-related quality of life (HRQoL), compromising their physical health and emotional well-being. QoL is equally distributed among different social groups. The aim of this study to analyze the impact of clinical characteristics and social determinants of health on the QoL of a cohort of persons diagnosed and/or treated for cancer. Methods: We performed a cross-sectional study in a cohort of 155 with various stages of cancer at different stages of their disease. Data were obtained using questionnaires QLQ-C30 from the European Organization for Research and Treatment of Cancer (EORTC), which include a set of functional and symptomatic scales. We conducted descriptive and bivariate analysis using the Chi-Square test, Anova Test and adjusted for relevant variables using logistic regression. The dependent variables were the functional scales of QoL and the independent variables were socio-demographic and clinical variables. Results: Among the participants, 80(51.6%) were male and 75(48.4%) were female and majority 66(42.6%) in between the age of 40-60 years. Large proportion of patients were diagnosed with Oral cancer 67(43.2%), and Breast cancer 23(14.8%), and the clinical stages during the beginning of therapy were maximum at stage II a 104(67.1%). The mean of global health status/QoL was 52.34 (SD= 23.34). Quality of life was found to be significantly associated with some functional scales as role functioning (P?0.001), social function, (P=0.00), and symptom scales as pain (P=0.00), loss of appetite (P=0.004) and financial impact (P=0.02) as well as associations were noted in relation to socio demographic characteristics. Women from the most disadvantaged class, and showed the poorest results for most of the function scales. In contrast, age, education, occupation and social status had differential effects depending on the function studied. The highest functional status was cognitive functioning (54.58�.68). Conclusions: The cancer diagnosis has become more prevalent and carries significant changes to the method of living with physical and emotional changes in term of quality of life (QoL) because of inconvenience, torment, disfigurement, reliance and loss of confidence. In addition, addressing the unmet needs of these patients and ensuring higher satisfaction rate are recommended to maintain adequate HRQoL.

Quality of life assessment in patients who have undergone oncologic resection of rectum: a retrospective, three arms, single centre, observational study

Background: Quality of life (QOL) analysis following cancer surgery is a sensitive issue among patients. The present study tried to find the status of these QOL parameters in patients who had undergone oncogenic resection of rectum.Methods: Patients were given the short form 36 (SF-36), The European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 and the EORTC QLQ-C29 questionnaires to fill at three time points in their treatment (prior to surgery, 3 months and 6 months following surgery). The prospectively collected questionnaires were analysed retrospectively.Results: On comparing SF-36 questionnaire, there was significant improvement as we proceeded from baseline to first and second visit except for the energy level. On EORTC-30 questionnaire, there was significant improvement in all scales as we proceeded from baseline to first visit and then to second visit. On comparing EORTC-29 questionnaire, among all visits of abdominoperineal resection (APR), symptoms like pain and blood or mucus in stools significantly improved, low anterior resection (LAR) showed significant improvement in all 4 scales, high anterior resection (HAR) patients showed worst micturition complaints during first visit and gradually improving scores for other scales from baseline to first and second visit.Conclusions: The three-questionnaire used in the study comprehensively included all issues from general health after cancer surgery to problems faced by the patients specifically after various modalities of rectal surgery. Such studies should be planned routinely to assess comprehensive outcome of oncogenic surgeries.

Effect of treatment on the quality of life of cervical cancer patients: a prospective study from a tertiary care centre of West Bengal

Background: Cervical cancer is one of many health care ironies. Better survival rates demand better quality of life (QoL). The aim of present study was to determine the change in QoL of cervical cancer patients due to treatment.Methods: An observational prospective study was conducted from July 2017 to June 2018 among 80 new cervical cancer patients without any prior history of treatment for cervical cancer, attending radiotherapy department of a tertiary care centre of West Bengal using a semi-structured schedule and European Organization for Research and Treatment of Cancer (EORTC) quality of life questionnaire (QLQ). Information was collected on socio-demographic and clinical aspects and QoL domains. Those with history of surgery for cervical cancer, advanced stage of disease were excluded. EORTC QLQ was administered at baseline and one month after completion of treatment. Data was analysed by percentage, means±standard deviation, range and Wilcoxon signed rank test etc. using SPSS-16.Results: Only 60 patients could be analysed as 10 patients died and 10 lost to follow-up. After treatment there was a significant improvement in global health, physical, emotional and cognitive functioning as well as decrease in symptoms like fatigue, pain, insomnia, appetite loss and constipation along with worsening of financial difficulties. There was significant improvement in body image, decrease in problems of symptom experience, peripheral neuropathy and menopausal symptoms after treatment.Conclusions: The cervical cancer patients show an overall improvement in their QoL in most of the domains after one month of treatment except worsening of financial difficulties.

Quality of life of oral and oropharyngeal cancer patients attending a tertiary care institute in Kolkata

Background: Assessment of quality of life (QOL) helps to find out factors associated with disease progression and response to treatment, identify vulnerable groups. The objective of this study was to assess the QOL (based on physical, mental, social, emotional and spiritual dimensions) of oral and oropharyngeal cancer patients.Methods: A hospital based cross sectional study was conducted among 126 oral and oropharyngeal cancer patients attending radio therapy department of Calcutta Medical College. QOL was assessed by using validated Bengali version of two self-administered questionnaires: European Organization for the Research and Treatment of Cancer (EORTC)-30 and EORTC-35.Results: Among total 81 patients, most of the patients (45.67%) had stage III diseases. Median global health score (GHS) for all patients were 41.67. GHS deteriorated with advancement of the diseases (p=0.000), GHS significantly improved with increasing level of education (p=0.019). GHS was poorer among female patients (median for male was 45.66 and for female was 36.45; p=0.178) and patients with oropharyngeal cancer (median for oral cancer was 50.00, oropharyngeal cancer was 41.67, p=0.215). As per EORTC-35, pain was the major symptom for both type of cancer and was more among patients with oropharyngeal cancer.Conclusions: QOL deteriorates with advancement of the disease and is poorer among females. Co-morbidity status does not affect the QOL. Pain is a major problem of cancer patients, which is more with oropharyngeal cancer patients. Early detection of the cancer and proper pain management and counselling with special focus on females can improve the quality of life.

Quality of life and health of breast cancer woman survivors in Popayan-Colombia / Calidad de vida y salud en mujeres sobrevivientes al cáncer de mama en Popayán- Colombia / Qualidade de vida e saúde em mulheres sobreviventes ao câncer de mama em Popayán, Colômbia

Objective: Identify the quality of life and its association with health parameters for breast cancer women survivors in Popayan, Colombia. Methods: Analytic crosssectional descriptive correlated study, with nonprobability sampling, according to the inclusion criteria of 39 women who survived breast cancer, who received a survey made by the authors which included sociodemographic aspects, evaluation of the quality of life through the questionnaire EORTC QLQ ­ BR23 and measurements such as the Body Mass Index (BMI), blood pressure and blood sugar levels, according to international standards. Results: The health indicators (blood pressure and blood sugar) are found under the normal ranges, while the BMI has a tendency for overweight. Regarding quality of life, high measurements for body image and sexual function were evidenced, while the dimensions of sexual pleasure and future perception showed intermediate measures. Regarding association, moderate correlations were observed between blood pressure and blood sugar levels, with body image and the sexual aspect. Conclusions: An association between the health indicators and the quality of life was observed, demonstrating the need to formulate prevention and intervention actions from an interdisciplinary vision. Also, it was observed that the quality of life requires a review toward self-confidence and relationship with oneself, through workshops or talks that allow to overcome limitations proper of the disease and to move on.

Objetivo: Identificar la calidad de vida y su asociación con parámetros de salud en mujeres sobrevivientes al cáncer de mama en Popayán, Colombia. Métodos: Estudio descriptivo-correlacional de corte transversal analítico, con una muestra no probabilística, de acuerdo con criterios de inclusión de 39 mujeres sobrevivientes al cáncer, a quienes se les aplicó una encuesta de elaboración propia con aspectos socio-demográficos, valoración de la calidad de vida mediante el cuestionario EORTC QLQ - BR23 y mediciones como el Índice de Masa corporal (IMC), presión arterial y niveles de glucemia, según estándares internacionales. Resultados: Los índices de salud (presión arterial y glucemia) se encontraron bajo los rangos de normalidad, mientras que para IMC hay tendencia de sobrepeso. Respecto a la calidad de vida, se evidenciaron mediciones elevadas para la imagen corporal y la función sexual, mientras que las dimensiones de disfrute sexual y percepción a futuro presentaron mediciones intermedias. Respecto a la asociación, se observaron correlaciones moderadas entre la presión arterial y los niveles de glucemia, con la imagen corporal y la parte sexual. Conclusiones: Se evidenció una asociación entre los indicadores de salud y calidad de vida, demostrando la necesidad de plantear acciones de prevención e intervención desde una visión interdisciplinaria. De la misma manera, se observó que la calidad de vida requiere una revisión hacia la autoconfianza y relación consigo misma, a través de talleres o charlas que permitan superar las limitaciones propias de la enfermedad y salir adelante.

Objetivo: Identificar a qualidade de vida e a sua associação com parâmetro de saúde em mulheres sobreviventes ao câncer de mama em Popayán, Colômbia. Métodos: Estudo descritivo-correlacional de corte transversal analítico, estudando uma a mostra probabilística de 39 mulheres sobreviventes ao câncer de mama, que responderam um instrumento de formulação própria com aspectos sociais e demográficos, avaliação da qualidade de vida empregando o questionário EORTC QLQ - BR23 e foram estabelecidos o índice de massa corporal (IMC), a pressão arterial e níveis de glicemia segundo padrões internacionais. Resultados: Os níveis de pressão arterial e glicemia encontraram-se nos rangos de normalidade, entretanto, o IMC mostrou a tendência ao sobrepeso. Na aferição da qualidade de vida, observaram-se medições elevadas na imagem corporal e função sexual, enquanto que as dimensões desfrute sexual e percepção do futuro presentaram aferições intermediarias. Na associação de variáveis houve uma moderada relação entre a pressão arterial e os níveis de glicemia com a imagem corporal e a parte sexual. Conclusões: Evidenciou-se a associação entre os indicadores de saúde e a qualidade de vida, demostrando a necessidade de formular ações de prevenção e intervenção desde uma perspectiva interdisciplinar. Do mesmo modo, observou-se que a qualidade de vida requer uma revisão dirigida à autoconfiança e relação com se mesma, através de oficinas ou conferencias que permitam superar as limitações próprias da doença e seguir em frente.

Quels facteurs influencent la qualité de vie des patients tunisiens atteints de cancer du poumon? / Which factors influence the quality of life of Tunisian patients with lung cancer?

Introduction - Les facteurs influençant la qualité de vie (QDV) des patients tunisiens atteints d'un cancer du poumon (CDP) sont méconnus.L'objectif de cette étude est d'identifier les facteurs influençant la QDV des patients tunisiens atteints d'un CDP. Méthodes - Un questionnaire médical a évalué les caractéristiques générales et spécifiques de 100 patients dont 90 hommes, et les questionnaires QLQ-C30 et QLQLC13 ont évalué la QDV. Résultats - Les femmes, les sujets âgés, les mariés et les analphabètes avaient une mauvaise QDV. Comparativement aux patients indemnes de comorbidités, ceux ayant une à deux comorbidités avaient des scores d'activités physiques et professionnelles/loisirs plus bas. Comparativement aux patients ayant un cancer datant de moins d'un an, ceux dont le cancer datait de plus d'un an avaient des scores de santé globale et d'activité physique plus bas, et des scores de nausées/vomissements, d'insomnie et d'anorexie plus élevés. Les patients en stade avancé avaient une mauvaise QDV en termes d'activités physique et émotionnelle, d'insomnie et de constipation. Les patients ayant des métastases avaient une mauvaise QDV en termes de score global, d'activité physique, de fatigue, d'insomnie, d'anorexie et de diarrhée. Le type histologique et le type de traitement n'influençaient pas la QDV. Le sexe n'influençait pas les scores du QLQ-LC13. Comparativement aux patients traités par chimiothérapie, ceux traités par la combinaison chimiothérapie et chirurgie avaient des scores de dyspnée et de neuropathie périphérique plus élevés. Conclusion - Les facteurs suivants influencent la QDV des Tunisiens atteints d'un CDP: le sexe, l'âge, l'état civil, le niveau de scolarisation, les comorbidités, le stade et la durée d'évolution du cancer, et les métastases. Comparativement aux patients traités par chimiothérapie, ceux traités par chimiothérapie et chirurgie avaient des scores de dyspnée et de neuropathie périphérique plus élevés

Introduction - No previous study has established the factors that influence the quality of life (QOL) of tunisian patients with lung cancer (LC).This study aims to identify the factors that influence QOL of tunisian patients with LC. Methods. A medical questionnaire assessed the general and specific characteristics of 100 patients (90 men), and structured questionnaires (QLQ-C30 and QLQ-LC13) assessed QOL. Results -Women, elderly, married and illiterate patients had poor QOL. Compared to patients free from comorbidity, those with one to two comorbidities had lower scores of physical and life-role activities. Compared to patients with cancer discovered less than one year ago, those who's cancer appeared more than one year ago had lower scores of global health, physical activity, nausea/vomiting, and higher scores of insomnia and anorexia. Patients with advanced cancer had poor QOL in terms of physical and emotional activities, and insomnia and constipation items. Patients with metastases had a poor QOL in terms of global health, physical activity, fatigue symptom, insomnia, anorexia, and diarrhea. The histological and treatment types did not influence QOL. The QLQ-LC13 scores were not influenced by sex. However, compared to patients treated with chemotherapy, those treated with chemotherapy and surgery had higher scores of dyspnea and peripheral neuropathy. Conclusion - The following factors influenced QOL of Tunisian patients with LC: sex, age, civil status, schooling level, comorbidities, LC stage and duration, metastases. Compared to patients treated with chemotherapy, those treated with chemotherapy and surgery had higher scores of dyspnea and peripheral neuropathy

Psychometric Validation Of The Bahasa Malaysia Version Of The Eortc QLQ-C30 In Malaysian Colorectal Cancer Patients

@#This study aimed to assess the validity and reliability of the Bahasa Malaysia (BM) version of European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire core (QLQ-C30) (version 3.0) in Malaysian patients with colorectal cancer. A cross sectional study design was used to obtain data from patients receiving treatment at two teaching hospitals in Kuala Lumpur, Malaysia. Self-administered method was used. Statistical analysis included reliability, convergent and discriminant validity and known-groups comparisons. Statistical significance was based on p value ≤ 0.05. The internal consistency Cronbach’s alpha coefficient (α) was acceptable (> 0.70) in all scales but cognitive (α = 0.56) and pain in patients with stoma bag (α = 0.35). Test-retest coefficients were high (r = 0.93 to 1.00). All items showed adequate convergent validity (r > 0.40) except for questionnaire item 5 “needs help in eating/dressing/washing”. Similarly, criteria for discriminant validity were achieved in all but item 10 “need rest”. Patients with high Karnofsky Performance Scores (KPS) scores reported significantly less dyspnoea (p = 0.021) and appetite loss (p = 0.047) compared to patients with low KPS scores. There was no significant difference between patients with and without stomas. The psychometric properties of the BM version of the QLQ-C30 were comparable to previous studies in other settings. Therefore, the questionnaire could be used to measure quality of life in Malaysian patients with colorectal cancer.

Internal Consistency Study of EORTC QLQ-C30 and QLQ-PR25 Questionnaires for Quality of Life Assessment among Prostate Cancer Patients in a University Hospital, Kuala Lumpur, Malaysia

@#Prostate cancer is forth most common diagnosed tumors in Malaysian male. The use of a self-reported, quality of life assessment is important for clinical practice, care taker and researcher to evaluate the level of quality of life. The aim of this study was to measure the internal consistency of the translated Malay Language EORTC QLQ-C30 and EORTC PR-25 questionnaires among prostate cancer patient at National University of Malaysia hospital in Kuala Lumpur, Malaysia. Methods This was a cross sectional study conducted between July 2017 and Dec 2017. The respondent comprised of 110 Malaysian prostate cancer patients who were under follow up at Urology and Oncology Clinic. Sets of translated Malay language EORTC QLQ C30 and EORTC PR-25 consisted of functional, symptom and global health status domains were administered to assess their quality of life. Results The translated questionnaires were acceptable by 110 respondents. Cronbach`s α coefficient result were 0.913 (EORTC QLQ-C30) and 0.829 (EORTC PR25) respectively suggested that this instrument had good internal consistency. Conclusions Our study confirmed that translated Malay language EORTC QLQ-C30 and QLQ-PR25 questionnaires are acceptable, reliable and valid instrument to be used among Malaysian prostate cancer patients.

A descriptive study to understand how severity of symptoms after completion of treatment impact on the life of oral cancer patients

Background: Oral cancer is a commonly occurring cancer among Indians, who are mostly habituated to chewing tobacco. It accounts for around 30–40% of all malignant tumors in India and has one of the lowest five years survival rates, as most of them are diagnosed in advanced stages. More so, after the treatment is completed, the patients’ still suffers from a number of symptoms, which are often not taken seriously. The objective of this study was to evaluate the impact of severity of symptomatology of oral cancer after completion of cancer treatment.Methods: EORTC (European organization for research and treatment of cancer) H and N 35 questionnaire (Marathi version) was used to assess the severity of clinical symptoms. 100 consecutive patients of oral cancer who had completed their treatment and came for follow up after 1 to 3 months of treatment completion were enrolled for the study after taking informed written consent. The study was initiated after obtaining ethical approval from the institutional ethics committee. Statistical analysis was done using R software.Results: Age of the patient, status of insurance, time gap between symptom onset and diagnosis, socio-economic status and stage of oral cancer were included in the final model of multivariate analysis. Time gap between symptom onset and diagnosis (in months) was also found to be associated significantly to head and neck symptoms. Participants from higher socio-economic status were found to have fewer head and neck symptoms and this association was found statistically significant.Conclusions: Assessment of severity of symptomatology should be routinely practiced among patients who had completed their treatment and come for follow up. This needs to be followed by guidance and individualized interventions for improving the quality of life of the treated patients.

Evaluation Of Quality Of Life In Nasopharyngeal Carcinoma Based On Eortc Qlq-H And N35 And Karnofsky Scale In Adam Malik General Hospital Medan

Introduction: Nasopharyngeal carcinoma (NPC) is a malignant epithelial cell that lines the nasopharyngeal surface and is aneck head malignancy that has received much attention due to the relatively high mortality rate. Evaluating the quality of lifefor patients with malignancies is important as an “end-point” for treatment and an indicator of patient monitors.Method: This study is an analytical study with cross-sectional research design by analyzing the EORTC QLQ-H and N35 andKarnofsky Scale on 60 NPC patients.Results: Most NPC patients were male, most in Stages III and IV. The most histopathological type is non crystallizing SCC.Based on EORTC QLQ-H and N35, the most complaints of patients with NPC were found to be weight loss and the use ofpainkillers Karnofsky scores of NPC patients who were assessed as having a mean of 70.33.Conclusion: There is a significant correlation between EORTC QLQ - H and N35 with Karnofsky scores (r = −0.612; P = 0.000).The greater the Karnofsky value, the smaller the value of EORTC QLQ - H and N35 means that the quality of life of the patientis getting better, and vice versa

Impacto del diagnóstico y tratamiento del cáncer de mama en la calidad de vida de las pacientes / Impact of breast cancer diagnosis and treatment on patients' quality of life

Introducción El cáncer de mama (cm) es la principal causa de muerte por enfermedad oncológica en mujeres. Con el aumento de su incidencia y de las tasas de sobrevida, resulta importante evaluar los efectos de la enfermedad en la calidad de vida (cv) de las pacientes. Objetivos Medir el impacto del diagnóstico y tratamientos del cm en la cv de las pacientes e identificar factores de riesgo (fr) para la afectación de las distintas dimensiones de la cv, a fin de brindar mejor contención e implementar medidas específicas. Material y método Es un estudio observacional, analítico, transversal. Se incluyeron pacientes con diagnóstico y tratamientos por cm en tiempos y lugares variables, tratadas actualmente en el Centro Mamario del Hospital Universitario Austral. La información se obtuvo a través de encuestas anónimas, que incluían dos cuestionarios que evaluaban cv en cáncer (eortc qlq-c30) y en cm específicamente (eortc qlq-br23) y un cuestionario propio. Resultados Se obtuvieron 171 encuestas. El promedio de cv fue bueno en todos los grupos. La escala de funcionamiento emocional fue la más afectada. Los síntomas más frecuentes fueron: fatiga e insomnio. El funcionamiento sexual y la preocupación por el futuro fueron las áreas de mayor afectación en el cuestionario específico de cm. Los síntomas específicos más reportados fueron las molestias por la pérdida del cabello. Logramos identificar al menos 10 fr con diferencias estadísticamente significativas. Conclusiones Resulta fundamental el conocimiento de la población tratada para medir el impacto de la enfermedad y de sus tratamientos y para reconocer los grupos más vulnerables. Esto permite no solo implementar medidas para mejorar la cv de las pacientes sino también mejorar la relación médicopaciente

Introduction Breast cancer (bc) is the main cause of death due to malignancy in women. With its rising incidence and prolonged survival rates, it is important to assess its effect on quality of life (qol) on women. Objectives To measure the impact of bc diagnosis and treatments on patients' qol and to identify wich risk factors (rf) play a role on qol, in orther to better understand, improve and develop patient centered care strategies. Materials and method This is a cross-sectional observational study of women with a diagnosis of bc who received treatment at different institutions, with different followup times, that are currently treated at the Breast Center of the Hospital Universitario Austral. Patients were evaluated via anonymous surveys, which included two questionnaires that evaluated qol in cancer (eortc qlq-c30) and in bc specifically (eortc qlq-br23), and a personalized questionnaire of our own. Results 171 surveys were obtained. The average qol was scored good among all groups. The emotional functioning scale was the most affected. The most frequent symptoms experienced were fatigue and insomnia. Sexual functioning and future perspectives were the most affected areas in the specific bc questionnaire. The specific symptom most commonly reported was upset by hair loss. At least 10 rf with statistically significant differences were identified. Conclusions Knowledge of the treated population is essential to assess the impact of the disease and its treatments, and to know the most vulnerable groups. This allows, not only the implementation of actions to improve patients' qol, but also to improve the doctor-patient relationship

Adaptación transcultural de la escala Caregivers Quality Of Life Index-Cancer para cuidadores en Colombia / Cross-cultural adaptation of the Colombian version of the Caregiver Quality of Life Index-Cancer (CQOLC)

Resumen Introducción: La mayoría de las escalas que evalúan la calidad de vida en cuidadores de pacientes oncológicos han sido elaboradas y validadas en idiomas diferentes al español, lo cual disuade su uso en población hispano-hablante. La escala Caregiver Quality Of Life Index-Cancer (CQOLC), que evalúa este constructo en este grupo poblacional, es el instrumento más empleado para tal fin; sin embargo, no se encuentra validada en Colombia. Considerando la relevancia de la evaluación de este constructo en el tratamiento integral de la población con cáncer, se presenta la traducción y adaptación transcultural al español colombiano de la escala CQOLC, para su posterior validación. Materiales y Métodos: Tras obtener el permiso del autor de la escala, ésta se tradujo directa e inversamente. Luego, se ejecutó la prueba piloto con una versión provisional en español, que identificó dificultades en la comprensión de los ítems o posibles molestias provocadas por los mismos. Resultados: La prueba piloto se ejecutó en 21 cuidadores de pacientes con cáncer que asistieron al Instituto Nacional de Cancerología en mayo del 2016. Durante la prueba piloto, se presentaron dificultades en la comprensión del ítem 5, por lo cual se decidió cambiar la redacción del mismo. El resto de los ítems se comprendieron fácilmente y se produjo una versión final del instrumento. Conclusión: Se encuentra disponible la escala CQOLC en español colombiano. Ésta escala podrá emplearse en el proceso subsiguiente de validación, para así estimar la calidad de vida de los cuidadores de pacientes con cáncer en el país.

Abstract Introduction: Most of the scales that evaluate quality of life in cancer care-givers have been designed and validated in languages different from Spanish which limits their utilization in Spanish-speaking population. The Caregiver Quality of Life Index-Cancer (CQOLC), which evaluated this construct in this specific group, is the most commonly used instrument in assessing quality of life among cancer caregivers. However, it is not validated in Spanish nor in Colombia. Considering the relevance of this construct as part of the comprehensive treatment of cancer patients, we present the translation and cross-cultural adaptation of the scale into Colombian Spanish. Methods: We obtained the author's permission. Then, the instrument was translated and back-translated. After that, we executed a pilot test with a provisional Spanish version, in order to identify difficulties at understanding items. Results: Pilot test was executed in 21 cancer caregivers that visited the Instituto Nacional de Cancerología on May 2016. During the pilot test, there was difficulty at understanding the 5th item of the scale. Therefore, we paraphrased it. There were not additional problems at understanding the other items, and the final Spanish version of the scale was released. Conclusion: The CQOLC in Colombian Spanish is available. Now, it is possible to use it in the ulterior validation process, in order to estimate quality of life in Colombian cancer caregivers.

Validity and reliability of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 – Tagalog among adult Filipinos with differentiated Thyroid Cancer / Journal of the ASEAN Federation of Endocrine Societies

Objective@#This study aims to determine the convergent and discriminant validity and internal consistent reliability of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30) Tagalog among adult Filipinos with differentiated thyroid cancer (DTC).@*Methodology@#104 adult Filipinos with DTC at various disease stages self-administered the EORTC QLQ-C30 version 3 Tagalog and Short Form-36 (SF-36) version 2 Tagalog. Concurrent validity between conceptually-related scales from both tools was determined. Convergent and discriminant validity of multi-item scales of the EORTC QLQ-C30 Tagalog were assessed by Spearman’s correlation. Cronbach's α was computed.@*Results@#The EORTC QLQ-C30 Tagalog showed moderate correlation with similar scales in the SF-36 Tagalog particulary for physical, role and social functioning, pain, and global health (r=0.42-0.48, p<0.001). It showed satisfactory item-domain convergent and discriminant validity for all scales except pain, fatigue, physical and cognitive functioning. Internal consistent reliability was good with cronbachs α ranging from 0.77 to 0.88 for global health, emotional and role functioning and symptom scale of nausea/vomiting.@*Conclusion@#The EORTC QLQ-C30 Tagalog had acceptable convergent and discriminant validity and internal consistent reliability for the scales of global health, role, social and emotional functioning and nausea/vomiting when applied among adult Filipinos with DTC.

Evaluating the Nutritional Status of Oncology Patients and Its Association with Quality of Life / 生物医学与环境科学（英文）

<p><b>OBJECTIVE</b>The primary aim of the study was to compare two nutritional status evaluation tools: the Patient-Generated Subjective Global Assessment (PG-SGA) and Nutritional Risk Screening (NRS-2002). Using the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire 30 (EORTC QLQ-C30), the second aim was to provide constructive advice regarding the quality of life of patients with malignancy.</p><p><b>METHODS</b>This study enrolled 312 oncology patients and assessed their nutritional status and quality of life using the PG-SGA, NRS-2002, and EORTC QLQ-C30.</p><p><b>RESULTS</b>The data indicate that 6% of the cancer patients were well nourished. The SGA-A had a higher sensitivity (93.73%) but a poorer specificity (2.30%) than the NRS-2002 (69.30% and 25.00%, respectively) after comparison with albumin. There was a low negative correlation and a high similarity between the PG-SGA and NRS-2002 for evaluating nutritional status, and there was a significant difference in the median PG-SGA scores for each of the SGA classifications (P < 0.001). The SGA-C group showed the highest PG-SGA scores and lowest body mass index. The majority of the target population received 2 points for each item in our 11-item questionnaire from the EORTC QLQ-C30.</p><p><b>CONCLUSION</b>The data indicate that the PG-SGA is more useful and suitable for evaluating nutritional status than the NRS-2002. Additionally, early nutrition monitoring can prevent malnutrition and improve the quality of life of cancer patients.</p>

Evaluation of RECIST, PERCIST, EORTC, and MDA Criteria for Assessing Treatment Response with Ga68-PSMA PET-CT in Metastatic Prostate Cancer Patient with Biochemical Progression: a Comparative Study / 대한핵의학회잡지

PURPOSE: The aim of the study was to compare response evaluation criteria in solid tumours 1.1 (RECIST 1.1), positron emission tomography response criteria in solid tumours (PERCIST), European organisation for research and treatment of cancer (EORTC), andMDAnderson (MDA) criteria for response assessment by Gallium 68-prostate-specific membrane antigen positron emission tomography-computed tomography (Ga68-PSMA PET-CT) in metastatic adenocarcinoma prostate cancer (mPCa) patients with biochemical progression.METHODS: Eighty-eight mPCa patients with pre and post treatment Ga68-PSMA PET-CTwere included. A ≥ 25% increase and ≥ 2 ng/ml above the nadir if prostate specific antigen (PSA) drop or ≥ 2 ng/ml above the baseline if PSA does not drop was considered as biochemical progression. RECIST 1.1 and MDA criteria for morphology and PERCIST and EORTC criteria for molecular response were investigated. Percentages of progressive disease (PD), partial response (PR), and stable disease (SD) were calculated. Chi-square test was used for statistical significance.RESULTS: Proportion of PD, SD, and PR by RECIST 1.1 and MDA criteria were 44 (50.57%), 39 (44.83%), 4 (4.6%), and 33 (39.76%), 48 (57.83%), 2 (2.41%) respectively. Proportion of PD, SD, and PR by PERCIST and EORTC criteria were 71 (80.68%), 11 (12.50%), 6 (6.82%), and 74 (84.09%), 8 (9.09%), 6 (6.82%) respectively. Chi-square test showed statistically significant (P < 0.05) higher proportion of progression detected by both molecular criteria as compare to both morphological criteria.CONCLUSION: We concluded that for Ga68-PSMA PET-CT response evaluation, molecular criteria performed better than morphological criteria in mPCa patient with PSA progression.

Nutritional Status and Quality of Life of Oncology Patients Prior to Pelvic Radiotherapy

Introduction: Malnutrition among cancer patients is associated with a higher risk of gastrointestinal toxicity which develops during treatment and may affect quality of life (QOL). Thus, this cross-sectional study aimed to determine the nutritional status and QOL of 30 oncology patients (mean age 50.0+10.7 years) prior to pelvic radiotherapy at Hospital Sultan Ismail, Johor Bahru. Methods: Patients were assessed for anthropometry measurements, 24-h diet recall and nutritional status using Scored Patient-Generated Subjective Global Assessment (PG-SGA) questionnaire while the European Organization for Research and Treatment of Cancer Care Quality of Life Questionnaire (EORTC QLQ-C30) was used to assess QOL two weeks prior to the initiation of pelvic radiotherapy. Results: Mean Body Mass Index (BMI) of patients was 23.3+3.3kg/m2 and 33% of patients experienced weight loss prior to pelvic radiotherapy. The PG-SGA rating indicated that 63% of patients were at Stage A (well-nourished) and 37% were in Stage B (moderate malnutrition). The PG-SGA numerical score was a significant predictor of QOL, after adjusting for socio-demographic factors (R2=0.861, p<0.05). Conclusion: In general, the low nutritional status of the patients indicates the need for early nutritional assessment, education and intervention in ensuring optimal nutritional status throughout the pelvic radiotherapy treatment.

Percepción de la calidad de vida y satisfacción con la asistencia sanitaria recibida en un grupo de pacientes oncológicos terminales que reciben cuidados paliativos en un hospital de Zaragoza, España / Perceived quality of life and satisfaction with health care received in a group of terminal cancer patients receiving palliative care in a hospital in Zaragoza, Spain

Fundamento y objetivo: Mediante este estudio se buscó conocer la calidad de vida percibida por pacientes oncológicos terminales que reciben cuidados paliativos, así como la influencia que tiene la satisfacción con la asistencia sanitaria en la calidad de vida de estos pacientes. Se utilizaron escalas de la EORTC para conseguir esta información. Material y método: Estudio descriptivo transversal con 47 pacientes oncológicos terminales con cuidados paliativos en la unidad de hospitalización de oncología del Hospital Clínico Universitario Lozano Blesa de Zaragoza (España), durante febrero, marzo y abril de 2014. Se evaluó la calidad de vida y la satisfacción con la asistencia sanitaria a través de los cuestionarios EORTC QLQ C15-PAL y EORTC INPATSAT32. Resultados: Los participantes fueron en un 57,4% hombres, con 64 años de edad media, y todos tuvieron una persona principal de apoyo, siendo la pareja sentimental en un 74,5%. Los diagnósticos más frecuentes fueron: cáncer de pulmón, mama y colon. Los pacientes consideraron que tenían una calidad de vida buena con una media de 51,77 puntos, medida con el cuestionario EORTC QLQ C15-PAL. La satisfacción con la asistencia sanitaria medida con el cuestionario EORTC INPATSAT32 mostró una satisfacción media con la asistencia de medicina, enfermería y con los servicios y organización con 57,78, 57,54 y 52,2 puntos respectivamente. En general, los pacientes estuvieron muy satisfechos con la asistencia, con una media de 83 puntos. Conclusiones: Los pacientes obtuvieron una calidad de vida buena, y estuvieron muy satisfechos con la asistencia sanitaria en general, sin establecer relación entre esta y la calidad de vida.

Background and objective: The aim of this study is to determine the perceived quality of life of terminal cancer patients receiving palliative care, and the influence of health care satisfaction in the quality of life of these patients. EORTC scales were used to collect this information. Patients and methods: Descriptive cross-sectional study was conducted on 47 terminal cancer patients on palliative care in the Oncology Unit of the «Hospital Clínico Universitario Lozano Blesa¼, Zaragoza (Spain), during February, March and April 2014. The quality of life and the satisfaction with the health care were evaluated using the EORTC QLQ C15-PAL and EORTC INPATSAT32 questionnaires. Results: The participants had a mean age of 64 years, and included 57.4% males. All participants had a main support person, being their partner in 74.5% of cases. The most frequent diagnoses were lung, breast and colon cancer. Patients considered they had a good quality of life with a mean of 51.77 points, calculated with EORTC QLQ C15-PAL questionnaire. The satisfaction with health care, calculated with EORTC INPATSAT32, showed a good satisfaction with the medication and nursing care, as well as with the services and organisation, with 57.88, 57.54, and 52.2 points, respectively. In general, patients were very satisfied with the health care provided, with a mean score of 83 points. Conclusions: The patients obtained a good quality of life, and they were very satisfied with the health care in general, although there was no relationship between the two.

The validation of EORTC QLQ-STO22 scale in patients with gastric cancer in China / 肿瘤研究与临床

Objective To test the effectiveness, reliability and acceptability of the European Organization for Research and Treatment of Cancer (EORTC) QLQ-STO22 scale in gastric cancer patients in China. Methods One hundred and twenty-eight cases were collected in the Affiliated Cancer Hospital of Xiangya School of Medicine of Central South University from September 2014 to April 2015. All the patients completed the EORTC QLQ-STO22 and EORTC QLQ-C30 scales and given the Zubrod-ECOG-WHO (ZPS) score. Karen Bach coefficient and Pearson correlation test were used for statistical analysis while using ZPS score to detect EORTC QLQ-STO22 in validity. After score was standardized, P<0.05 represented the difference had statistical significance. Results The Karen Bach coefficient was 0.607-0.830, confirming that the EORTC QLQ-STO22 scale had good reliability. A number of enhanced analysis showed that the scale had good convergent validity and divergent validity. In the same or similar dimension, EORTC QLQ-C30 and EORTC QLQ-STO22 scales had good correlation and the correlation scores were higher than 0.400. The patients were divided into four groups according to ZPS score, with ZPS score increase, the overall quality of life scores were decreasing and entries associated with symptoms were increasing, showing difference between different groups(P<0.05). Conclusion The EORTC QLQ-STO22 scale shows high reliability and validity that can be used for assessing the quality of life of patients with advanced gastric cancer in China.

18F-FDG PET/CT imaging in the monitoring of response to sorafenib in patients with radioiodine- refractory differentiated thyroid cancer / 中国癌症杂志

Background and purpose:The evaluation of treatment response is one of the most important building blocks in determining the best strategy for the management of malignant tumors. In lymphoma and several solid cancer types, PET/CT-based response evaluation has been shown to be valuable, especially in visualizing the effect of the targeted treatment, which induces tumor activity changes not necessarily followed by tumor shrinkage. This study aimed to evaluate the role of18F-FDG PET/CT in the monitoring of response to sorafenib treatment in radioiodine-refractory differentiated thyroid cancer (RR-DTC) patients; and to compare the Response Evaluation Criteria in Solid Tumors (RECIST 1.1) with the European Organization for Research and Treatment of Cancer (EORTC) criteria.Methods:This was a single-center retrospective analysis of 14 patients with RR-DTC treated with sorafenib in the period from Dec. 2011 to Dec. 2014. A Wilcoxon signed-rank sum test was used to assess the differences in percentage changes between the sum of diameter and ∑SUVmax. These values of responses were statistically compared using the chi-square test (Fisher’s exact test). The differences in PFS between response categories according to either RECIST 1.1 or the EORTC criteria were evaluated using the Wilcoxon signed-rank sum test. The Spearman rank correlation coefficient was estimated between PFS and either morphologic (RECIST 1.1) or metabolic response (EORTC criteria) categories.Results:There was an agreement between the RECIST 1.1 and EORTC criteria in 10 of the 14 patients (χ2=2.345,P=0.424). The remaining 4 patients with SD in-cluded 2 patients with PMR and 2 patients with PMD. Differences in PFS among different response categories according to either RECIST 1.1 (χ2=8.571,P=0.003) or EORTC criteria (χ2=8.781,P=0.003) were statistically significant. Correlations were found between PFS and either morphologic (r=0.741,P=0.002) or metabolic (r=0.816,P=0.0004) response criteria. Conclusion:18F-FDG PET/CT imaging is of value in the monitoring of response to sorafenib in patients with RR-DTC. Although RECIST 1.1 and EORTC criteria agree in 71.4% patients, PET-based metabolic response criteria seems to be more accurate in predicting therapeutic outcome and may be more suitable than morphologic response criteria for the eval-uation of response to targeted therapy.

Postoperative Quality of Life after Total Gastrectomy Compared with Partial Gastrectomy: Longitudinal Evaluation by European Organization for Research and Treatment of Cancer-OG25 and STO22

PURPOSE: The European Organization for Research and Treatment of Cancer quality-of-life questionnaire-OG25 was developed to evaluate the quality of life in patients with stomach and esophageal cancer. The following are included in the OG25 but not in the STO22: odynophagia, choked when swallowing, weight loss, trouble eating with others, trouble swallowing saliva, trouble talking, and trouble with coughing. In this study, we evaluated the quality of life of gastrectomized patients using both, the OG25 and the STO22. MATERIALS AND METHODS: A total of 138 patients with partial gastrectomy (PG) (distal gastrectomy=91; pylorus-preserving gastrectomy= 47) and 44 patients with total gastrectomy (TG) were prospectively evaluated. Body weight and scores from the OG25 and STO22 were evaluated preoperatively and at 3 weeks, 3 months, and 6 months after surgery. RESULTS: Patients with TG had significant weight loss compared to patients with PG. At 3 months, TG was associated with worse scores for dysphagia, eating, odynophagia, trouble eating with others, trouble with taste, and weight loss on the OG25. TG was also associated with dysphagia, eating restrictions, and anxiety on the STO22. The OG25 helped differentiate between the groups with respect to weight loss, odynophagia, choked when swallowing, and trouble eating with others. The OG25 scores changed over time and were significantly different. CONCLUSIONS: The OG25 is a more sensitive and useful scale than the STO22 for evaluating the quality of life of gastrectomized patients, especially those with total gastrectomy.